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  • Title: N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles.
    Author: Zhang ZJ, Zhang L, Geng RL, Song J, Chen XH, Gong LZ.
    Journal: Angew Chem Int Ed Engl; 2019 Aug 26; 58(35):12190-12194. PubMed ID: 31250946.
    Abstract:
    Highly enantioselective [3+3] and [3+4] annulations of isatin-derived enals with ethynylethylene carbonates and ethynyl benzoxazinanones are enabled by NHC/cooper cooperative catalysis, leading to a big library of spirooxindole derivatives in high structural diversity and enantioselectivity (up to 99 % ee). Both reactions represent a nicely synergistic integration of NHC and copper catalysis, in which both catalysts activate the substrates and the chiral NHC perfectly controls the stereochemistry.
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