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  • Title: The development of alfentanil infusions for cardiac anaesthesia.
    Author: de Lange S.
    Journal: Eur J Anaesthesiol Suppl; 1987; 1():13-6. PubMed ID: 3126049.
    Abstract:
    Experience gained using alfentanil during cardiac surgery promoted the development of a variable-rate alfentanil infusion for general surgery that was titrated in such a way that post-operative ventilatory support was avoided. The empirical method of adjusting dosage to clinical response, as currently applied to inhalational anaesthesia, proved to be a useful experimental method of defining dosage schemes before adequate knowledge of the pharmacodynamic and pharmacokinetic variables of alfentanil was available.
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