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  • Title: Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review.
    Author: McBurney-Lin J, Lu J, Zuo Y, Yang H.
    Journal: Neurosci Biobehav Rev; 2019 Oct; 105():190-199. PubMed ID: 31260703.
    Abstract:
    The locus coeruleus-norepinephrine (LC-NE) system is involved in many brain functions and neurological disorders. In this review we discuss how LC-NE signaling affects the activity of cortical and subcortical sensory neurons, and how it influences perception-driven behaviors associated with mammalian somatosensory, visual, auditory, and olfactory systems. We summarize the consistent as well as seemingly inconsistent findings across brain areas and sensory modalities and propose a framework to understand these phenomena from the perspective of adrenergic receptor expression, dose-dependent physiology and excitation-inhibition balance. We also discuss potential future research directions in this field.
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