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  • Title: Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy.
    Author: Linhart B, Freidl R, Elisyutina O, Khaitov M, Karaulov A, Valenta R.
    Journal: Nutrients; 2019 Jun 29; 11(7):. PubMed ID: 31261965.
    Abstract:
    Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.
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