These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Electronystagmographic study in rabbits on the vestibular effect of vincamine.
    Author: Hamann KF, Bernhold B, Sattler B, Iatraki L.
    Journal: Arzneimittelforschung; 1979; 29(1):34-8. PubMed ID: 312648.
    Abstract:
    Vincamine (Vincapront), the alcaloid isolated from Vinca minor L, was tested in rabbits at three dosages (1 mg/kg, 5 mg/kg, 10 mg/kg i.m.) in an electronystagmographic study. The parameters evaluated were: duration, rate and frequency of the post-rotatory nystagmus and the frequency of the per-rotatory nystagmus. While the post-rotatory nystagmus was found to show a reduction in duration and rate, the frequencies did not respond to vincamine. The 1 mg/kg dose had the strongest effect while that of the 10 mg/kg dose was weakest. As these findings may not be explained by sedative or habituation effects we consider the reduction of the post-rotatory nystagmus as an analogue in animal experiments of the vestibular effect seen in man. The electronystagmographic pattern of action corresponds to that of some other antivertiginous drugs.
    [Abstract] [Full Text] [Related] [New Search]