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  • Title: [Usefulness of the evaluation of plasma levels of primidone and phenobarbital].
    Author: Franzoni E, Mambelli M, Masoni P, Govoni M.
    Journal: Pediatr Med Chir; 1987; 9(5):599-600. PubMed ID: 3126490.
    Abstract:
    We tested 187 blood samples to measure Primidone and Phenobarbital plasma levels. 63 were on monotherapy, whereas 124 on polytherapy. We founded a good relationship between PRI dosage and PB plasma levels. However, from our data, we can't find any correlation between PRI dosage and PRI level. Looking at correlations of polytherapy, BDZ and DPA do not change PRI and PB levels, whereas CBZ and DPH increase PB and decrease PRI, probably by inducing the biotransformation of the drug. In conclusion, we suggest the usefulness to measure together PRI and PB levels in order to obtain the best evaluation.
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