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  • Title: Superoxide dismutase mimetic nanoceria restrains cerulein induced acute pancreatitis.
    Author: Khurana A, Anchi P, Allawadhi P, Kumar V, Sayed N, Packirisamy G, Godugu C.
    Journal: Nanomedicine (Lond); 2019 Jul; 14(14):1805-1825. PubMed ID: 31267840.
    Abstract:
    Aim: The present study was carried out to assess the effect of nanoceria (NC) on pancreatic inflammation caused by cerulein. Methods: NC was characterized and in vitro studies were carried out in murine macrophages. The in vivo effects were tested on cerulein-induced pancreatitis. Results:In vitro treatment with NC remarkably protected macrophages from lipopolysaccharide-induced inflammation and oxidative stress as evident from the results of 2',7'-dichlorofluorescin diacetate, JC-1 and MitoSox staining. In vivo treatment with NC showed potent superoxide dismutase and catalase mimetic activity, antipancreatitis activity and improved histology. Furthermore, it reduced the expression of p65-NF-κB and acetylation of histone H3 at lysine K14, K56 and K79 residues. Conclusion: We for the first time, demonstrate that NC may be a promising candidate for the therapy of pancreatitis.
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