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  • Title: Long-term recurrences of jaw osteoradionecrosis after apparent healing with the PENTOCLO protocol.
    Author: Dinnoo A, Bidault F, Lassau N, Elmaalouf M, Moya-Plana A, Ruffier A, Janot F, Benmoussa N.
    Journal: J Stomatol Oral Maxillofac Surg; 2020 Jun; 121(3):286-287. PubMed ID: 31271892.
    Abstract:
    Osteoradionecrosis of the jaws (ORNJ) is a late complication of head and neck irradiation estimated at around 3% of irradiated patients. The PENTO protocol (Pentoxyfilline and Tocopherol), with the eventual adjunction of Clodronate (PENTOCLO), showed interesting results even in advanced ORNJ. The current literature does not describe the long-term outcomes and particularly after the completion of the protocol. The PENTO or PENTOCLO protocol should be prescribed as a life-long treatment or the outcome should be monitored at least as long as the duration of the protocol after its end.
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