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  • Title: Induction of ovulation with luprolide acetate and human menopausal gonadotropin.
    Author: Lewinthal D, Taylor PJ, Pattinson HA, Corenblum B.
    Journal: Fertil Steril; 1988 Apr; 49(4):585-8. PubMed ID: 3127242.
    Abstract:
    Four women with unexplained infertility and two anovulatory oligomenorrheic women who experienced repeated premature luteinization when treated with human menopausal gonadotropin (hMG) or gonadotropin-releasing hormone (GnRH) were given the gonadotropin-releasing hormone agonist (GnRHa), luprolide acetate, in order to effect medical hypophysectomy. This was followed by hMG for induction of ovulation. Four of the six patients had hMG-only cycles, which were compared with the luprolide acetate/hMG cycles. The luprolide acetate/hMG cycles resulted in normal folliculogenesis with presumptive ovulation. In luprolide/hMG cycles, significantly more hMG was needed for induction of ovulation than in hMG-only cycles. Premature luteinization was abolished with luprolide acetate treatment.
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