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  • Title: Reshaping human antibodies for therapy.
    Author: Riechmann L, Clark M, Waldmann H, Winter G.
    Journal: Nature; 1988 Mar 24; 332(6162):323-7. PubMed ID: 3127726.
    Abstract:
    A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.
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