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  • Title: Near-infrared spectroscopic applications in pharmaceutical particle technology.
    Author: Razuc M, Grafia A, Gallo L, Ramírez-Rigo MV, Romañach RJ.
    Journal: Drug Dev Ind Pharm; 2019 Oct; 45(10):1565-1589. PubMed ID: 31282753.
    Abstract:
    Near-infrared spectroscopy (NIRS) is nowadays an established analytical technique in the pharmaceutical industry. The aim of this review is to present the progress of NIRS in providing useful information for pharmaceutical particle technology. NIR methods are now developed to characterize a wide variety of materials (active pharmaceutical ingredients, excipients, co-processed powders, and physical mixtures) and pharmaceutical dosage forms (conventional, modified drug release technologies, and phytomedicines). This review also provides a number of spectra to illustrate the fundamental understanding of NIRS which has been gained. The sampling that must occur prior to the acquisition of near-infrared spectra is also discussed, as well as developments in monitoring mixing, tableting, and coating. This review will be valuable for product formulation and process engineering specialists.
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