These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Metabolic effects of combined oral contraceptive preparations.
    Author: Singh BM, Nutter SA, Nattrass M.
    Journal: Contraception; 1987 Dec; 36(6):651-8. PubMed ID: 3128428.
    Abstract:
    Fasting intermediary metabolite concentrations were measured in comparable groups of women either in the follicular or luteal phase of the menstrual cycle or taking low-dose estrogen combined oral contraceptive preparations. Blood total ketone bodies concentrations were significantly elevated in oral contraceptive users (p less than 0.05 v follicular and luteal groups) whilst blood alanine levels were lower (p less than 0.01 v follicular). Intermediary metabolite concentrations were measured in overnight fasted young women either in the follicular or luteal phase of the menstrual cycle or taking oral contraceptive (OC) preparations to determine changes due to the female sex hormone. The 1st group of 10 subjects was studied around the midpoint of the follicular phase of the menstrual cycle. The 2nd group of 10 subjects was studied around the midpoint of the luteal phase. Subjects in these groups menstruated regularly, and the 1st day of menses was considered to be day 1 of the cycle. The 3rd group of 10 women was using combined OCs containing 30-35 mcg of ethinylestradiol with either 125-250 mcg levonorgestrel or 1 mg norethisterone as the progesterone. The studies were performed during the final week of pill taking with the oc taken the night prior to the morning of blood sampling. There were no significant differences between the group when comparing age, weight, or body mass index. In the luteal compared to follicular phase women, fasting levels of estradiol and progesterone were significantly higher. Significant differences were observed for blood alanine concentrations. These were significantly lower in the OC group compared to women in the follicular phase of the menstrual cycle. Results in the luteal phase women were intermediate between follicular phase and OC groups. Significant differences were found in 3-OHB concentrations with significantly higher levels in the OC group compared to women in the follicular or luteal phase of the menstrual cycle. There were no significant differences when comparing fasting data of OC users taking preparations containing either levonorgestrel or norethisterone. Compared to women in the follicular phase of the menstrual cycle, blood alanine concentrations were significantly lower with levonorgestrel and norethisterone containing preparations. Compared to the follicular phase of the menstrual cycle, 3-OHB concentrations were significantly higher with either levonorgestrel or norethisterone but not when compared to women in the luteal phase.
    [Abstract] [Full Text] [Related] [New Search]