These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Anti-ischemia effect of continuous 24-hour infusion of glyceryl trinitrate in patients with stable angina pectoris].
    Author: Schneider W, Kett U, Kaltenbach M.
    Journal: Dtsch Med Wochenschr; 1988 Apr 08; 113(14):543-7. PubMed ID: 3128439.
    Abstract:
    In a placebo-controlled, double-blind trial with intraindividual changes in a randomized sequence, 12 patients received either glyceryl trinitrate (Perlinganit), 3 mg/h, or a placebo (physiological saline) via a perfusion system continuously for 24 hours. All had been shown to have angiographically demonstrated coronary heart disease, stable angina and exercise-inducible ischaemia reaction in the electrocardiogram (ST-segment depression). The ischaemia reaction in the exercise ECG (sum of ST-segment depressions) 90 min after onset of the infusion was improved by a mean of 45% during glyceryl trinitrate compared with the placebo response (P less than 0.001). At the end of the 24-hour period of infusion, however, no significant anti-ischaemic effect was any longer demonstrable (diminution of the ischaemia reaction by 15%). The glyceryl trinitrate-induced effect, after 90 min infusion, on arterial systolic pressure (-14%; P less than 0.01) and heart rate (+17%; P less than 0.001) during standing, was also no longer demonstrable after the 24-hour infusion. Thus the haemodynamic and antiischaemic effects of glyceryl trinitrate in the described dosage were largely absent after continuous 24-hour intravenous infusion. The causes of this rapid loss of effect are most likely to be sought in counter regulatory events, e.g. activation of neurohumoral mechanisms.
    [Abstract] [Full Text] [Related] [New Search]