These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Risk factors of hepatitis B virus infection between vaccinated and unvaccinated groups among spouses in 2006 and 2014: a cross-sectional study in Beijing.
    Author: Guo Y, Gao P, Wang H, Wu J, Bai Q, Huang L, Li S, Lv M, Shi X.
    Journal: Hum Vaccin Immunother; 2020; 16(1):148-157. PubMed ID: 31287778.
    Abstract:
    Objectives: To assess the prevalence of hepatitis B virus (HBV) infection among married individuals and to analyze the associated risk factors of HBV infection in vaccinated and unvaccinated groups in 2006 and 2014.Methods: Information of married individuals aged over 16 y with a clear HBV vaccination status was extracted from the database constructed by the Beijing Center for Disease Prevention and Control from population-based investigation.A structured questionnaire was employed to collect demographic information, vaccinated history, and other related influence information of HBV of participants. Pearson chi-square test, Fisher's test, and logistic regression were used to explore the risk factors of HBV infection.Results: A total of 2874 individuals in 2006 and 1622 individuals in 2014 were enrolled in our study. The mean age of individuals was 49.30 and 46.68 y in 2006 and 2014, respectively. The overall positive rates of HBsAg, anti-HBc, and single anti-HBs were 4.80%, 43.01%, and 5.78% in 2006, which were 4.69%, 38.22%, and 14.18% in 2014, respectively. For vaccinated individuals, age was significantly correlated with anti-HBc in 2014 (40 < age ≤50 versus age ≤30, relative risk (RR) = 3.03, 95% confidence interval (95%CI) = 1.04-8.84). Gender [male versus female, RR = 0.60, 95%CI = 0.36-1.00 (2006); RR = 0.71, 95%CI = 0.52-0.97 (2014)] and age (in 2006) were found to be significantly associated with single anti-HBs.For unvaccinated individuals, HBsAg positivity was statistically significant correlated with gender [RR = 1.47, 95%CI = 1.04-2.06, in 2006], residence (urban versus rural, RR = 0.40, 95%CI = 0.24-0.67, in 2006; RR = 0.58, 95%CI = 0.34-0.99, in 2014), sharing syringes [RR = 3.75, 95%CI = 1.33-10.63 (in 2006); RR = 2.07, 95%CI = 1.26-3.41 (in 2014)], infected wives (RR = 1.97, 95%CI = 1.28-3.05, in 2006), and infected husbands (RR = 2.19, 95%CI = 1.25-3.82, in 2006). Anti-HBc positivity was significantly associated with gender [RR = 1.19, 95%CI = 1.10-1.30 (in 2006); RR = 1.24, 95%CI = 1.09-1.40 (in 2014)], age (in 2006 and 2014), endoscopic medicine treatment [RR = 1.16, 95%CI = 1.03-1.32 (in 2006), RR = 1.21, 95%CI = 1.01-1.45 (in 2014)], sharing syringes (RR = 1.43, 95%CI = 1.25-1.64, in 2014), body piercing (RR = 0.84, 95%CI = 0.75-0.93, in 2006), infected wives (RR = 1.32, 95%CI = 1.18-1.47, in 2006), and infected husbands (RR = 1.39, 95%CI = 1.22-1.59, in 2006). Anti-HBs positivity was associated with age (in 2006 and 2014).Conclusions: Prevalence of HBV infection was lower in 2014 than in 2006 according to HBsAg and anti-HBc positivity. Unvaccinated individuals faced much more risk of HBV infection than those of vaccinated.
    [Abstract] [Full Text] [Related] [New Search]