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  • Title: Stimulation of arachidonic acid metabolism by human slow-reacting substances.
    Author: Seale JP, Piper PJ.
    Journal: Eur J Pharmacol; 1978 Nov 01; 52(1):125-8. PubMed ID: 31288.
    Abstract:
    Human slow-reacting substance of anaphylaxis (SRS-A) and calcium ionophore-induced human SRS released prostaglandin-like substances and rabbit aorta contracting substance (RCS) from guinea-pig lungs. This effect was abolished by incubation of SRS-A and SRS with arylsulphatase or pretreatment of the lungs with indomethacin. Human SRS-A and SRS therefore resembled guinea-pig SRS-A in stimulating arachidonic acid metabolism. These results provide further evidence for a similar (or identical) nature of human SRS-A and SRS and suggest a possible role for slow-reacting substances in the release of prostaglandins during anaphylaxis.
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