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  • Title: Comparison of toxicokinetic parameters of a drug and two metabolites following traditional and capillary microsampling in rat.
    Author: Verhaeghe T, Dillen L, Stieltjes H, Zwart L, Feyen B.
    Journal: Bioanalysis; 2019 Jun; 11(13):1233-1242. PubMed ID: 31298569.
    Abstract:
    Aim: Following the request of a regulatory authority, a rat study was conducted to compare pharmacokinetic parameters from traditional large volume sampling and capillary microsampling. Materials & methods: Rats were dosed with a proprietary compound in three dose groups and blood samples were collected via capillary microsampling (32 μl), immediately followed by traditional large volume sampling (300 μl) up to 24 h postdose. Resulting plasma samples were analyzed for parent drug and two metabolites. AUCs were compared between sampling techniques. Results: There was no statistical difference between AUCs from traditional and microsampling across different doses and analytes. Conclusion: Toxicokinetic parameters generated from plasma collected as a capillary microsample or traditional large volume sample are highly comparable.
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