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  • Title: Signal-on fluorescence assay for pyrophosphate ions based on DNA-stabilized silver nanoclusters.
    Author: Xu H, Yu L, Zhang S, Xu X, Chen T, Ye H, Zhu X.
    Journal: Luminescence; 2019 Nov; 34(7):774-778. PubMed ID: 31304666.
    Abstract:
    Pyrophosphate anion (P2 O7 4- , PPi) is considered as a potential biomarker for arthritic diseases because high levels of PPi may result in calcium pyrophosphate dehydrate crystal deposition diseases. In this study, a simple fluorescence method for PPi was demonstrated by organic integration of the efficient fluorescence quenching ability of copper ions to DNA-scaffolded silver nanoclusters and the strong affinity of PPi towards copper ions. This simple fluorescence sensor showed a low detection limit (0.28 μM based on signal/noise = 3) towards the detection of PPi. Practical application of this method was also validated by detection of PPi in the synovial fluid.
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