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  • Title: A Solid-state Electrochemiluminescence Sensor for Detecting Glutathione with a Graphite-phase Carbon Nitride/Silica Modified Glassy Carbon Electrode.
    Author: Shan X, Shan X, Pan T, Dai F, Chen X, Wang W, Chen Z.
    Journal: Anal Sci; 2019 Dec 10; 35(12):1299-1304. PubMed ID: 31308299.
    Abstract:
    A solid-state electrochemiluminescence (ECL) sensor for the detection of reduced glutathione (GSH) based on a g-C3N4/SiO2 modified glass carbon electrode (GCE) has been developed in this research. The g-C3N4, which is employed as a luminophore, is simply prepared and exhibits an excellent ECL response. Mesoporous silica hollow spheres (SiO2) with a large specific surface area are introduced here to increase the loading amount of g-C3N4. Compared to a g-C3N4 modified GCE, the g-C3N4/SiO2 modified GCE displays a much higher ECL intensity. A high enhancement effect on the ECL intensity of g-C3N4/SiO2 modified GCE is obtained in the presence of GSH in the electrolyte. Moreover, the enhanced ECL intensity shows a good linear relationship to the GSH concentration in the range from 1.0 × 10-7 to 5.0 × 10-4 M, with a detection limit of 2.0 × 10-8 M (6.1 ng/mL). Besides, the ECL sensor exhibits a good anti-interference ability and has been successfully applied in the detection of GSH in commercial samples. The proposed sensor provides a promising platform for life science.
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