These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Technique and results of "low-dose" infusion.
    Author: Katzen BT.
    Journal: Cardiovasc Intervent Radiol; 1988; 11 Suppl():S41-7. PubMed ID: 3131007.
    Abstract:
    The results of 125 urokinase (UK) infusions in 108 patients were analyzed. Results showed total clot lysis in 61% of patients, partial lysis in 24%, and no lysis in 15%. Predictably, patients with acute occlusions had the highest incidence of complete clot lysis. However, clots older than 3 weeks had a surprisingly high lysis rate of 57%. None of the patients had a fibrinogen level below 100 mg/dL. Overall incidence of bleeding (major and minor) was 15%; patients having the most severe bleeding were on concomitant anticoagulation. We conclude that UK is a safe and effective therapeutic option in patients with acute and chronic obstruction. Significant bleeding episodes are uncommon during UK therapy and are related primarily to ongoing anticoagulation.
    [Abstract] [Full Text] [Related] [New Search]