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  • Title: Technique and results of "higher-dose" infusion.
    Author: McNamara T.
    Journal: Cardiovasc Intervent Radiol; 1988; 11 Suppl():S48-57. PubMed ID: 3131008.
    Abstract:
    We experimented with thrombolytic technique in an attempt to maximize therapeutic outcome, selecting urokinase because of its proven safety and efficacy in clinical investigation. An initially "high-dose" regimen, starting at 4,000 U/min and decreasing to 1,000 U/min after restoration of antegrade blood flow, generally establishes lysis within 3-4 h--even after acute embolic or thrombolytic occlusion. It can also be used effectively and safely as a therapeutic trial. "High-dose" urokinase compares favorably with "low-dose" streptokinase and shows a lower incidence of bleeding and allergic complications.
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