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  • Title: Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse.
    Author: Harada M, Nagata M, Takeuchi M.
    Journal: Experientia; 1988 May 15; 44(5):459-62. PubMed ID: 3131155.
    Abstract:
    Although IgE antibody is generally characterized as a homocytotropic antibody, it has been well known for some time that mouse IgE antibody causes potent sensitization of rat skin for PCA. The present study clearly shows the reciprocal cross-sensitization of mouse skin with rat IgE molecules. PCA and RPCA were produced by rat IgE antibody in an inbred mouse strain. DS/Shi, though not in C3H/HeShi, C57BL/6JShi and BALB/cCrj strains. Sensitization of DS/Shi mouse skin for PCA with rat IgE antibody was comparable in sensitivity with that of rat skin, but lasted only for a short term in comparison with the long persistence in rat skin.
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