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  • Title: Isolation and characterization of an immunosuppressive protein from Trichosanthes kirilowii root tubers.
    Author: Yeung HW, Poon SP, NG TB, Li WW.
    Journal: Immunopharmacol Immunotoxicol; 1987; 9(1):25-46. PubMed ID: 3131412.
    Abstract:
    An immunosuppressive protein was isolated from Trichosanthes kirilowii root tubers by a procedure involving acetone fractionation and ion exchange chromatography on CM-Sepharose. Homogeneity of the protein was demonstrated in immunoelectrophoresis, SDS-polyacrylamide gel electrophoresis, gel filtration, high performance liquid chromatography and a single NH2-terminal sequence. The protein had a molecular weight of 26,000, aspartic acid as the NH2-terminal amino acid and no cysteine or carbohydrates in its molecule. It inhibited ConA-induced transformation in lymphocytes isolated from spleens of CBA mice. The protein was also potent in inducing mid-term abortion in mice.
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