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  • Title: Stimulatory action of gamma-aminobutyric acid on catecholamine secretion from bovine adrenal chromaffin cells measured by a real-time monitoring system.
    Author: Kataoka Y, Ohara-Imaizumi M, Ueki S, Kumakura K.
    Journal: J Neurochem; 1988 Jun; 50(6):1765-8. PubMed ID: 3131482.
    Abstract:
    The present study was designed to evaluate the role of gamma-aminobutyric acid (GABA) in the secretory function of cultured chromaffin cells using the method of real-time monitoring. GABA evoked the secretion of catecholamines (CA) from adrenal chromaffin cells in a dose-dependent manner. Bicuculline 10(-5) M inhibited the stimulatory action of GABA. Diazepam 5 X 10(-6) and 2.5 X 10(-5) M facilitated the secretory response evoked by 7 X 10(-5) M GABA by 22% and 96%, respectively, which was antagonized by Ro 15-1788. This finding suggests that GABA-benzodiazepine receptor coupling can function in the secretion of CA from the adrenal chromaffin cells in a manner similar to that observed in the brain. GABA-evoked release of CA was reduced by 1 microM nifedipine to 16% of control, suggesting the involvement of voltage-sensitive Ca2+ channels in the mechanisms of the CA-releasing action of GABA in these cells. From these findings, the involvement of GABAergic mechanisms in the regulation of adrenal medullary function can be proposed.
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