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  • Title: Peritoneal dialysis clearance of cimetidine.
    Author: Vaziri ND, Ness RL, Barton CH.
    Journal: Am J Gastroenterol; 1979 Jun; 71(6):572-6. PubMed ID: 313152.
    Abstract:
    Peritoneal dialysis clearance of cimetidine was determined in two patients undergoing peritoneal dialysis treatment. The peritoneal dialysis clearance of cimetidine was approximately 10 ml./min. under optimal dialyzing conditions. The average cimetidine to creatinine extraction ratio was 0.45, which represents significant peritoneal dialyzability. The amount of cimetidine removed, however, constituted only a small fraction of the total administered dose. Therefore, only minor dose adjustments may be necessary during peritoneal dialysis treatment.
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