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  • Title: Generation of activated killer-like cells by OK-432-mediated production of interleukin 1, interleukin 2, and interferon-gamma in vitro.
    Author: Ujiie T.
    Journal: Jpn J Exp Med; 1987 Dec; 57(6):333-8. PubMed ID: 3131563.
    Abstract:
    Human peripheral blood mononuclear (PBM) cells incubated for 3 or more days in medium containing streptococcal preparation OK-432 developed toxicity to natural killer-resistant tumor cell lines. The generation of cytotoxic cells by OK-432 was potentiated by exogenous lymphokines such as interleukin 2 (IL-2) and interferon-gamma (IFN-gamma), the former being much more effective than the latter, and was blocked by antibodies to these cytokines such as interleukin 1 (IL-1), IL-2, and IFN-gamma. Although monocyte-depleted PBM cells were barely responsive to OK-432, they gave rise to activated killer (AK) cells after being incubated in medium with both IL-2 and IFN-gamma. Their generation was augmented by exogenous IL-1 but not by OK-432. These data indicate that AK-like cells are generated from human PBM cells through mediation of IL-1, IL-2, and IFN-gamma produced by OK-432 in vitro.
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