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  • Title: [Hemorheologic, metabolic and blood coagulation changes in diabetics in treatment with sulfanyl ureas].
    Author: Cortinovis A, Crippa A, Sciacca V, Caravaggio V, Crippa M.
    Journal: Minerva Med; 1988 May; 79(5):391-8. PubMed ID: 3131696.
    Abstract:
    A study was carried out to see if chronic treatment with a sulphanylurea with hypoglycaemic action, with also haemoactive action in terms of anti-platelet aggregation, profibrinolytic and antifibrinogenetic action also acted haemorheologically. For this purpose a group of patients treated with Gliclazide was compared with a group under treatment with Glibenclamide. A significant variation was noted in terms of an increase in erythrocyte filtrability and a diminution in erythrocyte aggregation with diminution in blood viscosity at low shear-rates. The absence of parallel modifications in quantitative corpuscular viscous factors, the early onset of the process, the real diminution in the sense of a reduction below the range of normality suggests that the effect is pharmacological and not mediated by metabolic compensation.
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