These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Taguchi method optimization for synthesis of Fe3O4 @chitosan/Tragacanth Gum nanocomposite as a drug delivery system.
    Author: Shafiee S, Ahangar HA, Saffar A.
    Journal: Carbohydr Polym; 2019 Oct 15; 222():114982. PubMed ID: 31320096.
    Abstract:
    Polysaccharides as natural hydrogels provide a promising strategy to prepare stimuli responsive drug carriers in pharmaceutical industries. In this work, Fe3O4 magnetic nanoparticles (MNPs) functionalized with (3-amino propyl) triethoxy silane (APTES) and coated by Chitosan (CS) and Tragacanth Gum (TG) to encapsulate curcumin. The synthesized nanocomposite was characterized using FT-IR, FE-SEM, EDX and XRD analysis. Taguchi Method (L9) with 3 levels and 4 variables was used to optimize the effect of concentration of Fe3O4@APTES, TG: CS ratio, nanocomposite weight, and curcumin weight on the drug loading. The release behaviour of curcumin was further studied in two different pH 7.4 and 3.4 and at temperatures 37 °C and 40 °C. The nanocomposite showed a higher swelling ratio at pH 3.4 and temperature 40 °C with good pH and thermosensitive in vitro drug release profiles. The results indicate that the nanocomposite has a good potential for delivery of chemotherapeutic drugs.
    [Abstract] [Full Text] [Related] [New Search]