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  • Title: Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.
    Author: Woods JS.
    Journal: Biochem Biophys Res Commun; 1988 May 16; 152(3):1428-34. PubMed ID: 3132158.
    Abstract:
    We have employed a model in vitro system for iron-peroxide-catalyzed oxidation of porphyrinogens to investigate the potential role of glutathione (GSH) in trace metal-induced porphyrias. GSH strongly attenuates porphyrinogen oxidation at biologically relevant concentrations in a dose-dependent manner. Porphyrinogenic trace metals reduce the effectiveness of GSH as a porphyrinogen antioxidant, leading to significantly higher rates of porphyrinogen oxidation to porphyrins. These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures.
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