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  • Title: Structure and expression of germ line immunoglobulin gamma 2b transcripts.
    Author: Lutzker S, Alt FW.
    Journal: Mol Cell Biol; 1988 Apr; 8(4):1849-52. PubMed ID: 3132612.
    Abstract:
    We have isolated a cDNA copy of a truncated C gamma 2b transcript produced by Abelson murine leukemia virus transformants that spontaneously switch from mu to gamma 2b. The initiation site of this transcript was 2 kilobases 5' to the gamma 2b switch recombination region, demonstrating its germ line origin. Nucleotide sequence analyses suggest that this transcript does not encode a protein. Expression of germ line gamma 2b transcripts in Abelson murine leukemia virus transformants and in normal spleen cells correlated with endogenous gamma 2b class switch activity.
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