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  • Title: Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.
    Author: Ghosn M, Carde P, Leclerq B, Flamant F, Friedman S, Droz JP, Hayat M.
    Journal: Bull Cancer; 1988; 75(4):391-2. PubMed ID: 3132998.
    Abstract:
    A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.
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