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  • Title: A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition.
    Author: Nasli-Esfahani E, Mohammadi-Khanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, Faramarzi MA, Bandarian F, Hamedifar H, Larijani B, Hajimiri M, Mahdavi M.
    Journal: Arch Pharm (Weinheim); 2019 Aug; 352(8):e1900034. PubMed ID: 31330079.
    Abstract:
    A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase.
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