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  • Title: Serum lipid profile in women using levonorgestrel contraceptive implant, Norplant-2.
    Author: Dash DS, Das S, Nanda U, Tripathy BB, Samal KC.
    Journal: Contraception; 1988 Apr; 37(4):371-82. PubMed ID: 3133159.
    Abstract:
    Cholesterol content of major lipoprotein fractions along with total cholesterol (Tc) and triglyceride (Tg) were measured in 65 samples from 35 women using levonorgestrel contraceptive implant, Norplant-2 from the third month of implantation until the end of second year along with twenty-five healthy controls. There were significant decreases in all the fractional lipid values, Tc and Tg, up to the sixth month followed by a gradual rise of all lipid parameters except HDLc which remained much below the control level. Interestingly, VLDLc exhibited a significant rise at the end of the second year. Total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), and very low density lipoprotein (VLDL) were measured in 35 Indian women using the levonorgestrel-containing implant, Norplant, and in 25 controls. 65 blood samples were taken from the 35 Norplant users at 3,6, 12 and 24 months after placing the implants. Assays were done by quantitative fractionation methods. Serum HDL fell significantly at 3 months (p0.02), and further over 6-24 months of use (p0.001), from 40.0 to 31.8 mg/dl. The control value was 49.2. LDL and VLDL fell to a minimum at 6 months, and rose somewhat at 12 and 24 months. Total cholesterol also was depressed to a mean of 128.8 at 6 months, then rose to 148 mg/dl at 24 months. Control total cholesterol was 190.1. Triglyceride levels followed a similar pattern. The ratios of HDL/total cholesterol and VLDL/total cholesterol in this series suggest increased risk of coronary heart disease. In contrast, the fall in total cholesterol to values below 100 mg/dl in some subjects is cause for concern. These data add to the widely discrepant findings of serum lipoproteins in different studies on Norplant users.
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