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  • Title: [Research on antibacterial and antifungal agents. VII. Synthesis of (1-pyrryl)methylquinolines acids].
    Author: Stefancich G, Corelli F, Massa S, Silvestri R, Panico S, Artico M, Simonetti N.
    Journal: Farmaco Sci; 1987 Jan; 42(1):3-16. PubMed ID: 3133240.
    Abstract:
    Some (1-pyrryl)methyl derivatives of 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid were synthetized by the standard procedure involving Gould-Jacobs and Lappin reactions. The above derivatives were tested microbiologically as nalidixic acid analogs and compared with some clinically useful 4-oxopyridine-3-carboxylic acids (nalidixic acid, pipemidic acid, norfloxacin, enoxacin and ciprofloxacin). Their antibacterial activities were very weak.
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