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  • Title: [Effect of glibenclamide on lipid metabolism in non-insulin-dependent diabetic patients].
    Author: Ratzmann KP, Schimke E, Herrmann C, Borngräber G, Meusel K.
    Journal: Z Gesamte Inn Med; 1988 Mar 01; 43(5):122-4. PubMed ID: 3133890.
    Abstract:
    In 25 newly registered type II diabetics the effect of a sulfonylurea therapy with manilil in contrast to an exclusive dietary treatment on serum triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol as well as the risk indices total cholesterol/HDL cholesterol and LDL cholesterol/HDL cholesterol were investigated within a period of treatment of 6 months. In comparable age, index of body weight and degree of the quality of metabolism (fasting blood glucose, HbA1) there are no differences between dietary treatment and combined diet-manilil-therapy concerning the lipid parameters investigated. There is a significant correlation between the quality of metabolism (fasting blood glucose concentration, HbA1), triglyceride and cholesterol concentration as well as the risk indices total cholesterol/HDL cholesterol and LDL cholesterol/HDL cholesterol. On the other hand, there is no relation between HDL cholesterol and the quality of metabolism. The findings do not speak for the fact that a sulfonylurea therapy is associated with an unfavourable effect on serum lipids, particularly on the HDL cholesterol.
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