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  • Title: Global Lung Function Initiative-2012 'other/mixed' spirometry reference equation provides the best overall fit for Australian Aboriginal and/or Torres Strait Islander children and young adults.
    Author: Blake TL, Chang AB, Chatfield MD, Marchant JM, McElrea MS.
    Journal: Respirology; 2020 Mar; 25(3):281-288. PubMed ID: 31339211.
    Abstract:
    BACKGROUND AND OBJECTIVE: Ethnic-specific reference equations are recommended when performing spirometry. In the absence of appropriate reference equations for Australian Aboriginal and/or Torres Strait Islanders (Indigenous), we determined whether any of the existing Global Lung Function Initiative (GLI)-2012 equations were suitable for use in Indigenous children/young adults. METHODS: We performed spirometry on 1278 participants (3-25 years) who were identified as Aboriginal, Torres Strait Islander or 'both'. Questionnaires and medical records were used to identify 'healthy' participants. GLI2012_DataConversion software was used to apply the 'Caucasian', 'African-American' and 'other/mixed' equations. RESULTS: We included 930 healthy participants. Mean z-scores for forced expiratory volume in 1 s (FEV1 ) and forced vital capacity (FVC) were lower than the Caucasian predicted values (range: -0.53 to -0.60) and higher than African-American (range: 0.70 to 0.78) but similar to other/mixed (range: 0.00 to 0.08). The distribution of healthy participants around the upper and lower limits of normal (~5%) fit well for the other/mixed equation compared to the Caucasian and African-American equations. CONCLUSION: Of the available GLI-2012 reference equations, the other/mixed reference equation provides the best overall fit for Indigenous Australian children and young adults (3-25 years). Healthy data from additional communities and adults around Australia will be required to confirm generalizability of findings.
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