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  • Title: [Synthesis and pharmacologic study of several spirohydantoins: relation to conformation].
    Author: Courtoison JC, Coudert P, Couquelet J, Tronche P, Jonadet M, Bastide P.
    Journal: Farmaco Sci; 1988 Feb; 43(2):153-60. PubMed ID: 3134252.
    Abstract:
    Using two routes starting from cyclanones, it has been possible to prepare two series of spirohydantoins substituted or not on the hydantoin nucleus nitrogen. These compounds exhibited low toxicity on pig lens aldose reductase (except for two compounds). A discussion is given on the steric and geometric requirements for effective enzyme inhibiting activity.
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