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  • Title: Effects of chronic sulpiride-induced hyperprolactinemia on menstrual cycles of normal women.
    Author: Oseko F, Morikawa K, Motohashi T, Aso T.
    Journal: Obstet Gynecol; 1988 Aug; 72(2):267-71. PubMed ID: 3134632.
    Abstract:
    We investigated the influence of chronic (27-65 days) sulpiride-induced hyperprolactinemia on the menstrual cycles of four normal women. The hyperprolactinemia (206.4 ng/mL, the average of the mean values of each subject obtained by sulpiride treatment) suppressed the LH surge and the secretion of plasma estradiol-17 beta and progesterone to their basal levels. The results suggest that the endocrine changes in normal women with sulpiride-induced hyperprolactinemia are similar to those in women with spontaneous hyperprolactinemia. Sulpiride-induced hyperprolactinemia may be useful as a model for studying spontaneous hyperprolactinemia.
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