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  • Title: Endogenous Opioid Dependence Induced in Rats by Periodic Intake of 5% Ethanol Solution.
    Author: Sudakov SK, Bogdanova NG, Alekseeva EV, Nazarova GA.
    Journal: Bull Exp Biol Med; 2019 Jul; 167(3):301-304. PubMed ID: 31346864.
    Abstract:
    We studied the possibility of formation of endogenous opioid dependence in rats during periodic intake of 5% ethanol solution. In the control group, both drinking bottles contained water. In the experimental group, the second bottle was filled with 5% ethanol solution for 12 h per day; in the following 12 h, these rats were deprived of food and ethanol. This regimen was maintained over 8 days. The rats were subdivided into alcohol- and water-preferring subgroups. Ethanol deprivation followed by naloxone injection evoked the signs of opiate withdrawal syndrome in both subgroups. These findings suggest that periodic voluntary intake of a weak ethanol solution over 8 days led to the formation of endogenous opioid dependence in rats irrespective of amount of the consumed alcohol.
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