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  • Title: [Interaction of chondroitin sulfate with enzymes].
    Author: Maksimenko AV, Terent'eva EL, Konovalova OIu, Torchilin VP.
    Journal: Ukr Biokhim Zh (1978); 1988; 60(2):20-5. PubMed ID: 3134758.
    Abstract:
    Chondroitin sulphate forms noncovalent electrostatic biocatalyst-glycosaminoglycan complexes in the solutions of enzymes. Chondroitin sulphate also interacts with enzymes developing complexes after carbodiimide activation of its carboxylic groups. Relatively low-molecular weight of biocatalysts (chymotrypsin, superoxide dismutase) forms stable noncovalent conjugates with the additional interaction as compared with electrostatic complexes. High-molecular weight of enzymes (acid phosphatase) develops covalent conjugates. Chondroitin sulphate is proposed for covalent binding of large proteins and multi-enzymatic complexes to obtain their stabilized derivatives for medical application.
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