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  • Title: Induction of ovulation with pulsatile GnRH: comparison between subcutaneous and intravenous administration in the same patients.
    Author: Riolo A, Carioni E, Lerro S, Albano M, Crippa A, Gelli D, Bini M, Pisoni P.
    Journal: Acta Eur Fertil; 1987; 18(4):271-5. PubMed ID: 3134780.
    Abstract:
    In this study we compared the results obtained during GnRH pulsatile therapy for ovulation induction in the same patients receiving successively GnRH by subcutaneous (10 mcg/90') and intravenous route (2.5 or 5 mcg/90'). Our data suggest that intravenous administration is the most effective procedure for restoring fertility, either in terms of hormonal levels (oestradiol and gonadotropin peaks) or ovulation rate (100% of ovulatory cycles on GnRH treatment versus 25% on subcutaneous administration). With regard to intravenous GnRH therapy, the dose of 2.5 mcg/90' may be more advisable and safe from ovarian overstimulation.
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