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  • Title: Serogroup diversity and antibiotic susceptibility of Neisseria meningitidis: Meningococcus infection monitoring in Belarus.
    Author: Kharkhal HN, Titov LP.
    Journal: Acta Microbiol Immunol Hung; 2019 Dec 01; 66(4):443-457. PubMed ID: 31355666.
    Abstract:
    This study performed an epidemiological survey of Neisseria meningitidis strains isolated from patients and from asymptomatic carriers. Altogether, 74 N. meningitidis strains (46 invasive and 28 non-invasive) were isolated between February 2011 and May 2018 in different regions of the Republic of Belarus. Serogenotyping was carried out by real-time PCR. Minimum inhibitory concentrations (MICs) of antibiotics were determined by broth microdilution and results were interpreted in accordance with EUCAST. The serogroups of N. meningitidis were determined as follows: serogroup B - 65%, C - 11%, W - 9%, A - 5%, Y - 4%, and Z and NG - 3% each. The MIC50 and MIC90 for benzylpenicillin (0.032/0.064-0.125 mg/L), ampicillin (0.032/0.125 mg/L), amoxicillin (0.125/0.25 mg/L), cefotaxime (0.016/0.016 mg/L), ceftriaxone (0.002/0.016 mg/L), ciprofloxacin (0.004/0.008 mg/L), chloramphenicol (1/1 mg/L), meropenem (0.008/0.008-0.016 mg/L), tetracycline (0.25/0.5 mg/L), and rifampicin (0.016/0.25 mg/L) were established. Strains with intermediate susceptibility for benzylpenicillin (12.3%), ampicillin (6.8%), and amoxicillin (24.7%) have been identified. In this study, we report the first rifampicin-resistant N. meningitidis in Belarus.
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