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  • Title: Effects of increasing serotonergic receptor activity in brain on prostagladin E1-induced fever in rabbits.
    Author: Lin MT, Pang IH, Chern SI, Chern YF.
    Journal: Pharmacology; 1979; 18(4):188-94. PubMed ID: 313571.
    Abstract:
    In rabbits, increasing serotonergic receptor activity or funtional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate the brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.
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