MEDLINE/PubMed Journal Browser Search

Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

Title: [Association between vitamin D level and lipid metabolism during second trimester].
Author: Jin D, Tao RX, Yin WJ, Yao MN, Yu WQ, Zhu P.
Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2019 Jul 10; 40(7):815-820. PubMed ID: 31357805.
Abstract:
Objective: To explore the relationship between the vitamin D levels and lipid metabolism during second trimester. Methods: A total of 1 875 pregnant women who were in the second trimester and had antenatal care in 3 hospitals in Hefei of Anhui province from March 2015 to February 2018 were included. Baseline questionnaire survey was performed, and fasting venous blood samples were collected from the pregnant women to detect serum 25(OH)D, cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels. Cubic non-linear model and linear regression model were used to analyze the linear relationship between vitamin D levels and lipid metabolism indicators in the second trimester. Results: The vitamin D deficiency rate was 75.3% (1 412/1 875) in the pregnant women. The mean levels of lipid metabolism indicators TC, TG, HDL-C and LDL-C were (233.22±38.87), (226.24±83.88), (79.04±12.77), and (109.54±25.95) mg/dl respectively. Multivariate linear regression model results showed, compared with Q5 of the 25(OH)D, the TC and TG levels of Q1-Q4 groups significantly increased, and the LDL-C of Q1 and Q2 groups significantly increased. The highest difference between TC, TG and LDL-C was observed in Q1 group. (TC: β=16.88, 95%CI: 10.50-23.26; TG: β=34.92, 95%CI: 21.32-48.53; LDL-C: β=9.06, 95%CI: 4.77-13.35). No significant differences in HDL-C level among the 5 groups were observed. When stratified with vitamin D deficiency the results showed that, when 25(OH)D was <50 nmol/L, TC, TG and LDL-C levels decreased by 3.53 (95%CI: 1.30-5.75), 7.42 (95%CI: 2.41 to 12.44) and 2.08 mg/dl (95%CI: 0.60-3.57) along with a 10 nmol/L increase of 25(OH)D, the difference was statistically significant, and when 25(OH)D was ≥50 nmol/L, no significant correlation was found between 25(OH)D level and TC, TG and LDL-C levels. No significant relationship between 25(OH)D level and HDL-C level was observed regardless of vitamin D deficiency. Conclusions: There was a nonlinear relationship between vitamin D levels and lipid metabolism indicators in the second trimester. There was a significant negative correlation between 25(OH)D level and lipid metabolism indicators only in the deficiency of vitamin D. 目的： 探讨孕中期维生素D水平与脂代谢指标的关系。 方法： 于2015年3月至2018年2月在合肥3家医院产科门诊招募1 875名处于孕中期的孕妇作为研究对象。进行问卷调查并留取清晨空腹静脉血，检测其血清25（OH）D、脂代谢指标TC、TG、HDL-C和LDL-C。采用Cubic非线性模型和线性回归模型分析孕中期维生素D水平与脂代谢指标间的关系。 结果： 孕中期维生素D缺乏率为75.3%，TC、TG、HDL-C和LDL-C均值分别是（233.22±38.87）、（226.24±83.88）、（79.04±12.77）和（109.54±25.95）mg/dl。多因素线性回归结果显示，以25（OH）D五分位组（Q1~Q5）中Q5为对照组，Q1~Q4组的TC、TG均显著升高，Q1和Q2组的LDL-C显著升高，且在Q1组观察到TC、TG和LDL-C的最高差值（TC：β=16.88，95%CI：10.50~23.26；TG：β=34.92，95%CI：21.32~48.53；LDL-C：β=9.06，95%CI：4.77~13.35）。未观察到5组间HDL-C的显著差异。以维生素D是否缺乏分层后结果显示，当25（OH）D<50 nmol/L时，25（OH）D每增加10 nmol/L，TC、TG和LDL-C分别降低3.53 mg/dl（95%CI：1.30~5.75）、7.42 mg/dl（95%CI：2.41~12.44）和2.08 mg/dl（95%CI：0.60~3.57），差异有统计学意义；而当25（OH）D≥50 nmol/L时，未发现25（OH）D与TC、TG和LDL-C间存在显著关联。无论维生素D是否缺乏，均未观察到25（OH）D与HDL-C的显著关系。 结论： 孕中期维生素D水平与脂代谢指标间存在非线性关系，仅在维生素D缺乏状态下，25（OH）D与脂代谢指标存在显著负相关。.

[Abstract] [Full Text] [Related] [New Search]