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  • Title: Intracellular localization of a leukocyte adhesion glycoprotein family in the tertiary granules of human neutrophils.
    Author: Lacal P, Pulido R, Sánchez-Madrid F, Cabañas C, Mollinedo F.
    Journal: Biochem Biophys Res Commun; 1988 Jul 29; 154(2):641-7. PubMed ID: 3135806.
    Abstract:
    Stimulation of human neutrophils by the chemoattractant formyl-methionyl-leucyl-phenylalanine or the calcium ionophore A23187 induced increments in the cell surface expression of the alpha subunits of Mo1 (CD11b) and gp150, 95 (CD11c) and their common beta subunit (CD18). These increases showed a good correlation with the extracellular release of gelatinase, a marker for tertiary granules in human neutrophils. Conversely, the cell surface expression of the alpha subunit of the lymphocyte function-associated antigen-1 or LFA-1 (CD11a) was not altered upon cell activation. By subcellular fractionation and immunoprecipitation studies, we have found that CD11b, CD11c and CD18 molecules were mainly localized in the membranes of tertiary granules, which were resolved from the specific and azurophilic granules as well as from the plasma membrane fraction.
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