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  • Title: 1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections.
    Author: Jalab M, Critchley ME, Taylor CM, Lawrence CL, Smith RB.
    Journal: Bioorg Chem; 2019 Oct; 91():103151. PubMed ID: 31362198.
    Abstract:
    The synthesis of a variety of 1,8-substituted anthraquinones, anthrones and bianthrones and their potential as antifungal agents is evaluated. Preliminary screening against Schizosaccharomyces pombe (S. pombe), a fission yeast, and Saccharomyces cerevisiae (S. cerevisiae), a budding yeast, is reported. Both these yeast species demonstrate close homologue to a number of pathogenic fungi.
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