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Title: Clinical Use of Polymyxin B. Author: Rigatto MH, Falci DR, Zavascki AP. Journal: Adv Exp Med Biol; 2019; 1145():197-218. PubMed ID: 31364080. Abstract: Polymyxin B is another clinically available polymyxin that has re-emerged in clinical practice to treat infections caused by multi-drug (MDR) or extensively-drug-resistant (XDR) Gram-negative bacteria (GNB). Its chemical structure is very similar to the structure of polymyxin E (colistin). However, since the latter is administered as a prodrug, there are major pharmacokinetic differences between both polymyxins that may potentially determine different clinical and microbiological outcomes. Studies addressing clinical or microbiological outcomes in patients treated with polymyxin B for MDR or XDR GNB are reviewed in this chapter.[Abstract] [Full Text] [Related] [New Search]