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  • Title: Impact of mutations in hVISA isolates on decreased susceptibility to vancomycin, through population analyses profile - area under curve (PAP-AUC).
    Author: Silveira ACO, Caierão J, Silva CI, Anzai EK, McCulloch JA, d'Azevedo PA, Sincero TCM.
    Journal: Diagn Microbiol Infect Dis; 2019 Nov; 95(3):114854. PubMed ID: 31366440.
    Abstract:
    We analyzed sequences of graSR, vraSR, walKR and rpoB genes in hVISA from Brazil. Five isolates showed mutations in at least one gene. rpoB H481N and graS T224I were the most frequent mutations, followed by graR D148Q and walK A468T. Our study reinforces the heterogeneity of genetic patterns among hVISA.
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