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  • Title: Use of a pharmacokinetic model to characterize the thyrotropin (TSH) and prolactin (PRL) response to thyrotropin-releasing hormone (THR) in man.
    Author: Perret G, Valensi P, Hugues JN, Vassy R, Uzzan B.
    Journal: Methods Find Exp Clin Pharmacol; 1988 Jun; 10(6):387-91. PubMed ID: 3137402.
    Abstract:
    On the basis of a pharmacokinetic model using the data of a TRH test and without the use of radio-isotope tracers, a simple procedure of estimation of PRL and TSH TRH-stimulated release and elimination half-lives is presented. TRH tests were performed in 33 healthy subjects and their data were used to calculate the kinetic parameters of each subject. Elimination half-lives of TSH and PRL were found to be respectively (mean +/- SD in min) 63 +/- 7.4 and 35 +/- 2.8. Release half-lives were 8.2 +/- 1.3 for TSH and 5 +/- 0.4 for PRL. The usefulness of the procedure in the evaluation of drug effects on pituitary secretion in man and the comparison with the literature data are discussed.
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