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  • Title: Tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice.
    Author: Sansone M, Castellano C, Libri V.
    Journal: Psychopharmacology (Berl); 1988; 95(2):176-9. PubMed ID: 3137594.
    Abstract:
    The opioid agonist-antagonist pentazocine (1-30 mg/kg) and the partial agonist buprenorphine (0.05-0.25 mg/kg) were tested, alone or in combination with the histamine H1-receptor antagonist tripelennamine (1, 2.5, 5 or 10 mg/kg), on locomotor activity in mice of the CD-1 strain. When given alone, pentazocine produced slight and non-dose-related activity increments, while buprenorphine induced strong and dose-related locomotor stimulation. Tripelennamine slightly increased activity by itself and enhanced buprenorphine-, but not pentazocine-induced hyperactivity. The results are discussed in relation to the hypothesis that antihistaminic agents specifically interfere with locomotor effects of opioids.
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