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  • Title: Protein A-positive staphylococci serve as a selective B cell mitogen for lymphocytes from primary immunodeficiency patients.
    Author: Sirianni MC, Pandolfi F, Aiuti F, Wigzell H.
    Journal: Clin Exp Immunol; 1979 Apr; 36(1):107-11. PubMed ID: 313858.
    Abstract:
    Staphylococcus aureus protein A-positive bacteria have recently been proposed as selective B lymphocyte mitogens. We have studied the lymphocyte response to such mitogens in bacteria in normal subjects and in patients with primary immunodeficiencies. Patients with primary T cell defects show a normal response to protein A-positive bacteria and impaired responses to PHA and Con A. In contrast, patients with Bruton agammaglobulinaemia respond normally to these T cell mitogens but not to the bacteria. Thus, protein A-positive bacteria fulfil the criteria for being a T cell-independent B cell mitogen for human peripheral blood cells.
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